Codeine has long been demonstrated to possess embryolethal and fetotoxic effects (diminished fetal entire body weights and delayed or incomplete ossification) while in the hamster, rat and mouse products at approximately two-4 times the utmost advised human dose of 360 mg/day according to a body area place comparison. Maternally poisonous doses that were approximately seven moments the utmost suggested human dose of 360 mg/working day, ended up associated with proof of resorptions and incomplete ossification, which include meningioencephalocele and cranioschisis.
Examine using your medical doctor straight away For those who have signs of pale or blue lips, fingernails, or pores and skin; tricky or troubled respiration; irregular, quick, gradual, or shallow respiration; or shortness of breath. These might be indications of a issue referred to as respiratory depression .
Promethazine may well interfere with blood grouping from the ABO procedure. The drug noticeably alters the flare reaction in intradermal allergen exams.
Codeine wasn't mutatgenic inside the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary mobile chromosome aberration assay.
To prevent or Command small allergic transfusion reactions in adults, twenty five mg of promethazine hydrochloride could be administered prior to or all through a blood transfusion.
Will not stop using codeine instantly after extended-phrase use, otherwise you could have disagreeable withdrawal indications. Check with your health practitioner how to securely halt making use of this drugs.
Tell all of your current well being care suppliers that you simply acquire this medicine (promethazine tablets). This involves your Medical doctors, nurses, pharmacists, and dentists. Stay clear of driving and carrying out other jobs or steps that call so that you can be notify or have distinct vision until the thing is how this drugs (promethazine tablets) affects you. This medication may well cause the results of some pregnancy exams to become Completely wrong. Talk with the health practitioner. When you have substantial blood sugar (diabetic issues), you will need to view your blood sugar carefully. Talk to your medical doctor before you decide to consume Liquor or use other medicine and natural products that slow your steps.
The general prevalence of sulfite sensitivity in the final inhabitants is not known but possibly low; such sensitivity seems to manifest a lot more routinely in asthmatic than in nonasthmatic people.
The analgesic Attributes of codeine are speculated to come from its conversion to morphine, although the exact system of analgesic action continues to be mysterious.
Notice: Medication Unwanted effects could possibly be underreported. In case you are suffering from Unwanted effects that are not mentioned, post a report back to the FDA click here by following this guideline.
Promethazine can be a phenothiazine derivative with powerful antihistaminic properties and shares the steps in the antihistamines.
Medicines that interact with promethazine may possibly possibly decrease its impact, have an affect on how long it works, boost side effects, or have significantly less of an influence when taken with promethazine. An conversation concerning two medications doesn't constantly necessarily mean that you simply need to more info end getting on the list of medications; nevertheless, at times it does.
Codeine sulfate can be expected to possess additive consequences when made check here use of along side Alcoholic beverages, other opioids, or illicit medicine that result in central nervous program melancholy, for the reason that respiratory despair, hypotension, profound sedation, coma or Dying may outcome.
If you more info think There was an overdose, get in touch with your poison Manage Centre or get clinical care right away. Be here wanting to tell or display what was taken, how much, and when it transpired. Usually asked thoughts